The book is mainly geared towards vaccination approaches as related to infectious diseases. The book discusses immunogen design for vaccines in both the conventional aspect and new breakthrough thinking such as reverse vaccinology approach by Rino Rappuoli. The book details vaccine development platforms such as VLPs (virus like particles), nanocapsules, cationic microparticles for DNA delivery and lays out successes and challenges in each of these areas. I would have loved to see more emerging aspects of human therapeutic vaccination processes such as cellular therapeutic vaccines for cancer (dendritic cell based vaccination; e.g. Provenge). The book, in very clearly articulated chapters, deal with characterization of immunogens through spectroscopy, biophysical aspects of proteins as well as characterization of particle delivery vehicles. One of the key aspects of modern day vaccination is formulation. This book in detail describes various aspects of formulation: both traditional (such as suspensions, emulsions) and more modern aspects such as the role of innate immunity in providing key danger signals to support subunit vaccines. The book's last part is devoted to clinical and regulatory aspects of vaccines. This is an evolving field and clearly things are changing at rapid pace with regulation of investigational vaccines.