This book introduces the reader to Serres' unique manner of 'doing philosophy that can be traced throughout his entire oeuvre: a novel way of bearing witness. It explores how Serres takes note of a range of epistemologically problematic situations, which he understands as arising from the short-circuit of a proprietary notion of capital with a praxis of science that commits itself to a form of reasoning that privileges the most direct path (simple method) to expend minimal efforts while pursuing maximal efficiency. In Serres' universal economy, value is considered a function of rarity, not a stock of resources. This book demonstrates how Michel Serres has developed an architectonics that is coefficient with nature. Mathematics and Information in the Philosophy of Michel Serres acquaint the reader with Serres' monist manner of addressing the universality and the power of knowledge - that is at once also the anonymous and empty faculty of incandescent, inventive thought. The book's chapters demarcate, problematize and contextualize some of the epistemologically problematic situations Serres addresses whilst also examining how he responds to and converses with these situations.