000			nam a22 7a 4500
999			_c39092 _d39092
008			190302b2001 xxu||||| |||| 00| 0 eng d
020			_a9780878933211
082			_a571.64 HIL-B
100			_aHille, Bertil
245			_aIonic channels of excitable membranes / _cBertil Hille
250			_a3rd
260			_aSunderland _bSinauer Associates _c2001
300			_a814 p.
365			_aUSD _b146.95.
500			_aIon channels underlie a broad range of the most basic biological processes, from excitation and signaling to secretion and absorption. Like enzymes, they are diverse and ubiquitous macromolecular catalysts with high substrate specificity and subject to strong regulation. This fully revised and expanded third edition of Ion Channels of Excitable Membranes describes the known channels and their physiological functions, then develops the conceptual background needed to understand their architecture and molecular mechanisms of operation. It includes new chapters on calcium signaling, structural biology, and molecular biology and genomics. Ion Channels of Excitable Membranes begins with the classical biophysical work of Hodgkin and Huxley, continues with the roles of channels in cellular signaling, then develops the physical and molecular principles needed for explaining permeation, gating, pharmacological modification, and molecular diversity, and ends with a discussion of channel evolution. Ion Channels of Excitable Membranes is written to be accessible and interesting to life scientists and physical scientists of all kinds. It introduces all the concepts that a graduate student should be aware of but is also effective in advanced undergraduate courses. It has long been the recognized authoritative overview of this field used by all neuroscientists.
650			_aNeurons
650			_aIon channels
650			_aExcitable membranes
650			_aMuscle cells
650			_aCell membranes
650			_aCellular signal transduction