000			02427nam a22002417a 4500
008			210701b2009 ||||| |||| 00| 0 eng d
020			_a9781493991907
082			_a616.12 GRO-D
100			_aGross, David R.
245			_aAnimal models in cardiovascular research / _cDavid R. Gross
250			_a3rd ed.
260			_aNew York _bSpringer _c2009
300			_a431 p.
365			_aINR _b3495.00.
500			_aAnimal Models in Cardiovascular Research covers both historical and recent advances in our understanding of the cardiovascular system from studies conducted in animal models. The last decade has seen an explosion in the use of very specialized congenic and transgenic animal models that were not described in the previous two editions. The results of many of these studies provide a sometimes bewildering array of redundant, overlapping and competing molecular pathways demanding further study. This third edition is designed to provide a better basis for understanding and using animal models in the current climate of background knowledge and information. The first and second editions of Animal Models in Cardiovascular Research emphasized normal cardiovascular parameters and the cardiovascular effects of a wide variety of drugs commonly used for restraint, anaesthesia and pain control in the various animal species. The third edition is focused on the avalanche of genetic, molecular and protein-based information generated from the use of both congenic and transgenic animal models. Updated and expanded chapters provide new information generated from classical, congenic and transgenic animal models used to study ischemic heart disease, cardiomyopathy, heart failure, hypertension and atherosclerotic disease. Completely new chapters in this third edition describe the techniques, problems and pitfalls associated with the measurement of cardiac and vascular function and ventricular/arterial coupling dynamics in various animal models. There is a new chapter detailing problems and pitfalls associated with isolated heart preparations and another describing animal models for the study of neurohumoral and CNS control of the cardiovascular system.
650			_aCardiovascular system--Diseases--Animal models
650			_aMedicine
650			_aCardiology
650			_aVeterinary medicine
650			_aPhysiology
650			_aLife sciences
650			_aCardiovascular system--Diseases
999			_c66554 _d66554